Created nanospheres for the treatment of Alzheimer’s disease
A group of researchers from India and France can achieve full recovery of long-term memory in mice with Alzheimer’s using a synthesized therapeutic molecules attached to the carbon nanospheres.
Initially, the researchers created the special substance that activates two enzymes (CBP and p300 histone acetyltransferases) to promote regeneration of brain neurons and prevents their destruction. Their presence also activates several genes that are important for memory. During the tests, the experimental mice was observed not only recovering 81% of the destroyed cells, but the formation of new connections, normalization of memory, reducing the load on the same neurons.
However, despite the unique therapeutic properties of the molecule of the substance could not overcome the blood-brain barrier and into the brain, so the team started looking for a solution for transportation. They are carbon steel spheres with a diameter of 400 nm, which are created using sugar.
Therapeutic molecules attached to the surface of the nanospheres, with whom reach the necessary parts of the brain. The penetration effect becomes possible due to the fact that the carbon spheres partially retain the properties of glucose, which feeds the cells. Nanosphere with a drug reaches the brain within 48 to 72 hours after introduction into the body and stay there for about 21 days.
In addition to the treatment of Alzheimer’s disease, the technology can be used to fight other damage of neurons, memory and neurodegradation. So far, the JNCASR team explores the long-term influence of components on the body and possible side effects. In the future they plan to launch their own startup.
Researchers from northwestern University of St. Louis is also dealing with issues of tissue regeneration. They have developed a biocompatible implant that helps restore the damaged peripheral nerves and completely decomposes in the body for a month.